Publications
Vitamin-D-receptor-gene polymorphisms and change in lumbar-spine bone mineral density
Abstract
Common vitamin-D-receptor (VDR) gene allelic variants predict bone mineral density. We analysed VDR alleles and rate of change of lumbar-spine bone mineral density over 18 months in 72 elderly subjects. 9 BB homozygotes lost bone mineral density but 26 homozygotes for the alternative genotype (bb) did not (mean change -2.3 [SE 1.0] vs 0.9 [0.7]% per year, p < 0.05), irrespective of calcium intake. Among 37 heterozygotes (Bb), however, change in bone mineral density correlated with calcium intake (r = 0.35, p < 0.03). This association between a genetic marker and rate of bone loss in the elderly suggests that the effect of calcium intake on maintenance of bone mass could relate to VDR gene polymorphisms.
| Type | Journal |
|---|---|
| ISBN | 0140-6736 (Print) |
| Authors | Ferrari, S.;Rizzoli, R.;Chevalley, T.;Slosman, D.;Eisman, J. A.;Bonjour, J. P. : |
| Publisher Name | LANCET |
| Published Date | 1995-01-01 |
| Published Volume | 345 |
| Published Issue | 8947 |
| Published Pages | 423-4 |
| Status | Published in-print |
| URL link to publisher's version | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7853953 |