Publications
Comparative effects of gold on the interactions of transcription factors with DNA
Abstract
We have previously hypothesized that a mode of action of the anti-rheumatic gold salt, aurothiomalate (AuTM), is the inhibition of DNA binding by transcription factors. Studies of the progesterone receptor (PR), which has a zinc finger structure in the DNA binding domain, were consistent with this hypothesis (1). Here we show that AuTM also markedly inhibits DNA binding by the transcription factor AP-1 and has less potent effects for AP-2, NF-1 and TFIID.
| Type | Journal |
|---|---|
| ISBN | 0379-0363 (Print) |
| Authors | Handel, M. L.;Sivertsen, S.;Watts, C. K.;Day, R. O.;Sutherland, R. L. : |
| Publisher Name | Agents Actions Suppl |
| Published Date | 1993-01-01 |
| Published Volume | 44 |
| Published Pages | 219-23 |
| Status | Published in-print |
| URL link to publisher's version | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8372730 |