Publications
A novel subtype of muscarinic receptor identified by homology screening
Abstract
A new member of the protein superfamily of G-protein coupled receptors has been isolated by homology screening. By virtue of its homology with other muscarinic acetylcholine receptors and its ability to bind muscarinic specific antagonists, this muscarinic receptor subtype is designated M4. The M4 mRNA is preferentially expressed in certain brain regions. The existence of multiple receptor subtypes encoded by distinct genes in the brain has functional implications for the molecular mechanisms underlying information transmission in neuronal networks.
| Type | Journal |
|---|---|
| ISBN | 0006-291X (Print) |
| Authors | Braun, T.;Schofield, P. R.;Shivers, B. D.;Pritchett, D. B.;Seeburg, P. H. : |
| Publisher Name | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS |
| Published Date | 1987-01-01 |
| Published Volume | 149 |
| Published Issue | 1 |
| Published Pages | 125-32 |
| Status | Published in-print |
| URL link to publisher's version | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=3120722 |