Publications
The modulatory capacity of interleukin-21 in the pathogenesis of autoimmune disease
Abstract
In this review, we discuss recent progress from studies on the biology of IL-21 and the role of this cytokine in the pathogenesis of autoimmunity. Recent studies have demonstrated that IL-21 plays an important and non-redundant role in a number of autoimmune animal models indicating that IL-21 could be a common modulator of the adaptive immune response towards self-tissue constituents in diseases such as systemic lupus erythematosus, models of rheumatoid arthritis, multiple sclerosis and type-1 diabetes. Also, the studies on the production of IL-21 in human autoimmune diseases and its behaviour on human cells in vitro are revealing the potential of IL-21 to exacerbate cellular processes that determine the course of autoimmune diseases.
| Type | Journal |
|---|---|
| ISBN | 1093-4715 (Electronic) |
| Authors | Vogelzang, A.;King, C. : |
| Publisher Name | Frontiers in Bioscience-Landmark |
| Published Date | 2008-07-01 |
| Published Volume | 13 |
| Published Pages | 5304-15 |
| Status | Published in-print |
| URL link to publisher's version | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18508588 |
| OpenAccess link to author's accepted manuscript version | https://publications.gimr.garvan.org.au/open-access/2399 |