Publications
An interferon-gamma-producing Th1 subset is the major source of IL-17 in experimental autoimmune encephalitis
Abstract
ThIL-17 (IL-17+/IFN-gamma-) cell lines are significantly more encephalitogenic than Th1 (IL-17-/IFN-gamma+) cell lines in adoptive transfer EAE models. In actively induced EAE short ex vivo peptide stimulation identifies an IL-17+/IFN-gamma+ population of CD4+ CNS-infiltrating MOG35-55-specific T cells, which outnumber IL-17+/IFN-gamma- cells by approximately 3:1 as disease develops. A decrease in numbers of IL-17+/IFN-gamma+ cells following in vitro culture is accompanied by an increase in IL-17-/IFN-gamma+ cell numbers. Together these ex vivo and in vitro observations imply that the Th1 lineage is more encephalitogenic than is suggested by adoptive transfer of Th1 (IL-17-/IFN-gamma+) cell lines which have been terminally differentiated in vitro.
| Type | Journal |
|---|---|
| ISBN | 0165-5728 (Print) |
| Authors | Suryani, S.;Sutton, I. : |
| Publisher Name | JOURNAL OF NEUROIMMUNOLOGY |
| Published Date | 2007-01-01 |
| Published Volume | 183 |
| Published Issue | 1-2 |
| Published Pages | 96-103 |
| Status | Published in-print |
| URL link to publisher's version | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17240458 |
| OpenAccess link to author's accepted manuscript version | https://publications.gimr.garvan.org.au/open-access/2291 |