Publications
Skin immunity in wound healing and cancer
Abstract
The skin is the body's largest organ. It serves as a barrier to pathogen entry and the first site of immune defense. In the event of a skin injury, a cascade of events including inflammation, new tissue formation and tissue remodeling contributes to wound repair. Skin-resident and recruited immune cells work together with non-immune cells to clear invading pathogens and debris, and guide the regeneration of damaged host tissues. Disruption to the wound repair process can lead to chronic inflammation and non-healing wounds. This, in turn, can promote skin tumorigenesis. Tumors appropriate the wound healing response as a way of enhancing their survival and growth. Here we review the role of resident and skin-infiltrating immune cells in wound repair and discuss their functions in regulating both inflammation and development of skin cancers.
Type | Journal |
---|---|
ISBN | 1664-3224 (Electronic) 1664-3224 (Linking) |
Authors | Jakovija, A.; Chtanova, T. |
Publisher Name | Frontiers in Immunology |
Published Date | 2023-06-30 |
Published Volume | 14 |
Published Pages | 1060258 |
Status | Published in-print |
DOI | 10.3389/fimmu.2023.1060258 |
URL link to publisher's version | https://www.ncbi.nlm.nih.gov/pubmed/37398649 |