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Importance of bone turnover for therapeutic decisions in patients with CKD-MBD

Abstract

Patients with chronic kidney disease-mineral and bone disorder (CKD-MBD) frequently have low bone formation rates. A recent review suggested that adynamic bone disease is not always associated with negative outcomes and therefore antiresorptive medications could be used more often. However, there is currently no evidence to support an improvement in fracture risk or mortality in patients with CKD-MBD and low bone turnover who are treated with antiresorptive medication. There is reasonable pathophysiological evidence suggesting that it may even be harmful.

Type Journal
ISBN 1523-1755 (Electronic) 0085-2538 (Linking)
Authors Ott, S. M.; Malluche, H. H.; Jorgetti, V.; Elder, G. J.
Responsible Garvan Author Professor Grahame Elder
Publisher Name KIDNEY INTERNATIONAL
Published Date 2021-09-30
Published Volume 100
Published Issue 3
Published Pages 502-505
Status Published in-print
DOI 10.1016/j.kint.2021.05.024
URL link to publisher's version https://www.ncbi.nlm.nih.gov/pubmed/34420656