Publications
Homo- and Heterotypic Association Regulates Signaling by the SgK269/PEAK1 and SgK223 Pseudokinases
Abstract
SgK269/PEAK1 is a pseudokinase and scaffolding protein that plays a critical role in regulating growth factor receptor signal output and is implicated in the progression of several cancers, including those of the breast, colon, and pancreas. SgK269 is structurally related to SgK223, a human pseudokinase that also functions as a scaffold but recruits a distinct repertoire of signaling proteins compared with SgK269. Structural similarities between SgK269 and SgK223 include a predicted alpha-helical region (designated CH) immediately preceding the conserved C-terminal pseudokinase (PK) domain. Structure-function analyses of SgK269 in MCF-10A mammary epithelial cells demonstrated a critical role for the CH and PK regions in promoting cell migration and Stat3 activation. Characterization of the SgK269
| Type | Journal |
|---|---|
| ISBN | 1083-351X (Electronic) 0021-9258 (Linking) |
| Authors | Liu, L. ; Phua, Y. W. ; Lee, R. S. ; Ma, X. ; Jenkins, Y. ; Novy, K. ; Humphrey, E. S. ; Chan, H. ; Shearer, R. ; Ong, P. C. ; Dai, W. ; Saunders, D. N. ; Lucet, I. S. ; Daly, R. J.; |
| Publisher Name | JOURNAL OF BIOLOGICAL CHEMISTRY |
| Published Date | 2016-01-01 |
| Published Volume | 291 |
| Published Issue | 41 |
| Published Pages | 21571-21583 |
| Status | Published in-print |
| OpenAccess link to author's accepted manuscript version | https://publications.gimr.garvan.org.au/open-access/13861 |