Publications
Dedicator of cytokinesis 8-deficient CD4+ T cells are biased to a TH2 effector fate at the expense of TH1 and TH17 cells.
Abstract
Dedicator of cytokinesis 8 (DOCK8) deficiency is a combined immunodeficiency caused by autosomal recessive loss-of-function mutations in DOCK8. This disorder is characterized by recurrent cutaneous infections, increased serum IgE levels, and severe atopic disease, including food-induced anaphylaxis. However, the contribution of defects in CD4+ T cells to disease pathogenesis in these patients has not been thoroughly investigated.
| Type | Journal |
|---|---|
| Authors | Tangye, SG.; Pillay, B.; Randall, L.; Avery, DT.; Phan, TG.; Gray, P.; Ziegler, JB.; Smart,JM.; Choo, S.; Peake, J.; Arkwright,PD.; Hambleton, S.; Oswaldo Lugo Reyes, S.; Orange, J.; Freeman, AF.; Uzel, G.; Su, HC.; Goodnow, CG.; Casanova, JL.; Ma, CS. |
| Responsible Garvan Author | Professor Stuart Tangye |
| Publisher Name | JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY |
| Published Date | 2017-03-01 |
| Published Volume | 139 |
| Published Pages | 933-949 |
| Status | Published in-print |
| DOI | 10.1016/j.jaci.2016.07.016 |
| URL link to publisher's version | https://www.ncbi.nlm.nih.gov/pubmed/27554822 |
| OpenAccess link to author's accepted manuscript version | https://publications.gimr.garvan.org.au/open-access/13432 |