Publications
Non-pharmacological and pharmacological strategies of brown adipose tissue recruitment in humans
Abstract
Humans maintain core temperature through a complex neuroendocrine circuitry, coupling environmental thermal and nutritional cues to heat-producing and dissipating mechanisms. Up to 40% of resting energy expenditure contributes to thermal homeostasis maintenance. Recent re-discovery of thermogenic brown adipose tissue (BAT) has brought the relation between ambient temperature, thermogenesis and systemic energy and substrate metabolism to the forefront. In addition to well-known pituitary-thyroid-adrenal axis, new endocrine signals, such as FGF21 and irisin, orchestrate crosstalk between white adipose tissue (WAT), BAT and muscle, tuning non-shivering and shivering thermogenesis responses. Cold exposure modulates the endocrine milieu, and cold-induced hormones cause bioenergetics transformation sufficient to impact whole body metabolism. This review will appraise the nature of human BAT and the basis of BAT-centred therapeutics, highlighting how the interaction between hormones and adipose tissue impacts metabolic responses. Non-pharmacological and pharmacological strategies of BAT recruitment and/or fat browning for metabolic benefits will be discussed.
Type | Journal |
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ISBN | 1872-8057 (Electronic) 0303-7207 (Linking) |
Authors | Lee, P. ; Greenfield, J. R.; |
Responsible Garvan Author | (missing name) |
Publisher Name | MOLECULAR AND CELLULAR ENDOCRINOLOGY |
Published Date | 2015-12-15 |
Published Volume | 418 Pt 2 |
Published Pages | 184-90 |
Status | Published in-print |
URL link to publisher's version | http://www.ncbi.nlm.nih.gov/pubmed/26026310 |
OpenAccess link to author's accepted manuscript version | https://publications.gimr.garvan.org.au/open-access/13216 |