Publications
The rise of regulatory RNA
Abstract
Discoveries over the past decade portend a paradigm shift in molecular biology. Evidence suggests that RNA is not only functional as a messenger between DNA and protein but also involved in the regulation of genome organization and gene expression, which is increasingly elaborate in complex organisms. Regulatory RNA seems to operate at many levels; in particular, it plays an important part in the epigenetic processes that control differentiation and development. These discoveries suggest a central role for RNA in human evolution and ontogeny. Here, we review the emergence of the previously unsuspected world of regulatory RNA from a historical perspective.
Type | Journal |
---|---|
ISBN | 1471-0064 (Electronic) 1471-0056 (Linking) |
Authors | Morris, K. V. ; Mattick, J. S.; |
Responsible Garvan Author | Professor John Mattick |
Publisher Name | NATURE REVIEWS GENETICS |
Published Date | 2014-01-01 |
Published Volume | 15 |
Published Issue | 6 |
Published Pages | 423-37 |
Status | Published in-print |
URL link to publisher's version | http://www.ncbi.nlm.nih.gov/pubmed/24776770 |
OpenAccess link to author's accepted manuscript version | https://publications.gimr.garvan.org.au/open-access/12400 |