Publications
RB1-mediated cell-autonomous and host-dependent oncosuppressor mechanisms in radiation-induced osteosarcoma
Abstract
The mechanisms by which retinoblastoma 1 (RB1) mediates oncosuppressive functions are still being elucidated. We found that radiation-induced senescence in the bone depends on RB1 and is associated with the secretion of multiple bioactive factors, including interleukin-6 (IL-6), as well as with the infiltration of natural killer T (NKT) cells. Importantly, the inhibition of RB1, IL-6 or NKT cells predisposed mice to radiation-induced osteosarcomas, unveiling a cancer cell-extrinsic mechanisms that underlie the oncosuppressive activity of RB1.
| Type | Journal |
|---|---|
| ISBN | 2162-4011 (Print) |
| Authors | Kansara, M. ; Thomas, D. M.; |
| Publisher Name | Oncoimmunology |
| Published Date | 2014-01-01 |
| Published Volume | 3 |
| Published Issue | 1 |
| Published Pages | e27569 |
| Status | Published in-print |
| URL link to publisher's version | http://www.ncbi.nlm.nih.gov/pubmed/24800165 |
| OpenAccess link to author's accepted manuscript version | https://publications.gimr.garvan.org.au/open-access/12361 |