Publications
New insights into signalling networks regulating breast cancer stem cells
Abstract
ABSTRACT: In a recent paper, Aceto and colleagues report that Src homology 2 domain-containing protein tyrosine phosphatase 2 (Shp2) plays a critical role in maintenance of breast tumour-initiating cells, and they define novel effectors downstream of Shp2 that regulate cellular invasion and self-renewal, including the transcription factors c-Myc and zinc finger E-box binding homeobox 1 and the suppressor of miRNA biogenesis lin-28 homolog B. These findings provide important mechanistic insights into breast tumourigenesis and highlight Shp2 as a potential therapeutic target. Breast Cancer Res. 2012 Sep 21;14(5):321.
| Type | Journal |
|---|---|
| ISBN | 1465-542X (Electronic) 1465-5411 (Linking) |
| Authors | Swarbrick, A.; Daly, R. J.; |
| Responsible Garvan Author | (missing name) |
| Publisher Name | BREAST CANCER RES |
| Published Date | 2012-01-01 |
| Published Volume | 14 |
| Published Issue | 5 |
| Published Pages | 321 |
| Status | Published in-print |
| URL link to publisher's version | http://www.ncbi.nlm.nih.gov/pubmed/22999218 |
| OpenAccess link to author's accepted manuscript version | https://publications.gimr.garvan.org.au/open-access/11622 |