Publications
Diimidazo[1,2-c:4',5'-e]pyrimidines: adenosine agonist activity demonstrated by microphysiometry
Abstract
Silicon-based microphysiometry, measuring extracellular acidification rate of cells in culture, demonstrated that a series of diimidazo[1,2-c:4',5'-e]pyrimidines were agonists at the human adenosine A1 receptor. 5-amino-7,8-dihydro-3-ribofuranose-8-(R)-(phenyl)-3H-diimidazo [1,2-c:4',5'-e]pyrimidine (2a) had an EC50 of 100 microM and reached 90% of the Emax produced by R-PIA.
| Type | Journal |
|---|---|
| ISBN | 0960-894X (Print) |
| Authors | Camp, D.;Green, J. M.;Kaiser, S. M.;Moni, R. W.;Townsend-Nicholson, A.;Schofield, P. R.;Quinn, R. J. : |
| Publisher Name | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS |
| Published Date | 1998-01-01 |
| Published Volume | 8 |
| Published Issue | 6 |
| Published Pages | 691-4 |
| Status | Published in-print |
| URL link to publisher's version | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9871584 |