Publications
TGF-beta puts the brakes on homeostatic proliferation
Abstract
The cellular mechanism by which the cytokine TGF-b maintains the homeostasis of mature T cells and prevents the emergence of severe lethal lymphoproliferative disease has remained obscure. It is now shown that TGF-b restrains the homeostatic T cell proliferation driven by self ligands from erupting into overt autoimmunity.
| Type | Journal |
|---|---|
| Authors | Surh, C. D.; Sprent, J.: |
| Publisher Name | NATURE IMMUNOLOGY |
| Published Date | 2012-06-19 |
| Published Volume | 13 |
| Published Issue | 7 |
| Published Pages | 628-30 |
| Status | Published in-print |
| DOI | 10.1038/ni.2345 ni.2345 [pii] |
| URL link to publisher's version | http://www.ncbi.nlm.nih.gov/pubmed/22713819 |
| OpenAccess link to author's accepted manuscript version | https://publications.gimr.garvan.org.au/open-access/11429 |