Publications
Synthesis and in vitro evaluation of analogues of avocado-produced toxin (+)-(R)-persin in human breast cancer cells
Abstract
A structure-activity study of several new synthetic analogues of the avocado-produced toxin persin has been conducted, with compounds being evaluated for their cytostatic and pro-apoptotic effects in human breast cancer cells. A 4-pyridinyl derivative demonstrated activity comparable to that of the natural product, suggesting future directions for exploration of structure-activity relationships.
| Type | Journal |
|---|---|
| Authors | Brooke, D.G.; Shelley, E.J.; Roberts, C.G.; Denny, W.A.; Sutherland, R.L.; Butt, A.J. |
| Publisher Name | BIOORGANIC & MEDICINAL CHEMISTRY |
| Published Date | 2011-11-03 |
| Published Volume | 19 |
| Published Issue | 23 |
| Published Pages | 7033-43 |
| Status | Published in-print |
| URL link to publisher's version | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=22044656 |
| OpenAccess link to author's accepted manuscript version | https://publications.gimr.garvan.org.au/open-access/11118 |