Publications
New sequence variants associated with bone mineral density
Abstract
In an extended genome-wide association study of bone mineral density among 6,865 Icelanders and a follow-up in 8,510 subjects of European descent, we identified four new genome-wide significant loci. These are near the SOST gene at 17q21, the MARK3 gene at 14q32, the SP7 gene at 12q13 and the TNFRSF11A (RANK) gene at 18q21. Furthermore, nonsynonymous SNPs in the C17orf53, LRP4, ADAM19 and IBSP genes were suggestively associated with bone density.
| Type | Journal |
|---|---|
| ISBN | 1546-1718 (Electronic) |
| Authors | Styrkarsdottir, U.; Halldorsson, B. V.; Gretarsdottir, S.; Gudbjartsson, D. F.; Walters, G. B.; Ingvarsson, T.; Jonsdottir, T.; Saemundsdottir, J.; Snorradottir, S.; Center, J. R.; Nguyen, T. V.; Alexandersen, P.; Gulcher, J. R.; Eisman, J. A.; Christiansen, C.; Sigurdsson, G.; Kong, A.; Thorsteinsdottir, U.; Stefansson, K.; |
| Publisher Name | NATURE GENETICS |
| Published Date | 2009-01-01 |
| Published Volume | 41 |
| Published Issue | 1 |
| Published Pages | 15-7 |
| Status | Published in-print |
| URL link to publisher's version | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19079262 |
| OpenAccess link to author's accepted manuscript version | https://publications.gimr.garvan.org.au/open-access/10233 |