Publications
Prevalence and pathogenesis of diabetes mellitus in HIV-1 infection treated with combined antiretroviral therapy
Abstract
Combined antiretroviral therapy (cART) in the treatment of HIV-1 infection confers significant survival benefit and, by immunoreconstitution, has altered the natural history of this life-threatening disease. Metabolic complications of cART include hyperlipidemia, insulin resistance, and lipodystrophy, with resultant increases in risk for type 2 diabetes and cardiovascular disease. These diseases will present new challenges in the management of HIV infection. This article reviews the prevalence of diabetes mellitus and its antecedents in HIV-infected patients treated with cART. It also reviews the current understanding of mechanisms involved in the pathogenesis of type 2 diabetes in cART considering insulin resistance and insulin secretion, both requisites for the development of type 2 diabetes mellitus.
| Type | Journal |
|---|---|
| ISBN | 1525-4135 (Print) |
| Authors | Samaras, K.; |
| Responsible Garvan Author | Professor Katherine Samaras |
| Publisher Name | JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES |
| Published Date | 2009-01-01 |
| Published Volume | 50 |
| Published Issue | 5 |
| Published Pages | 499-505 |
| Status | Published in-print |
| URL link to publisher's version | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19223782 |
| OpenAccess link to author's accepted manuscript version | https://publications.gimr.garvan.org.au/open-access/10229 |