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DNA G-Quadruplex and i-Motif Structure Formation Is Interdependent in Human Cells

Abstract

Guanine- and cytosine-rich nucleic acid sequences have the potential to form secondary structures such as G-quadruplexes and i-motifs, respectively. We show that stabilization of G-quadruplexes using small molecules destabilizes the i-motifs, and vice versa, indicating these gene regulatory controllers are interdependent in human cells. This has important implications as these structures are predominately considered as isolated structural targets for therapy, but their interdependency highlights the interplay of both structures as an important gene regulatory switch.

Type Journal
ISBN 1520-5126 (Electronic) 0002-7863 (Linking)
Authors King, J. J.; Irving, K. L.; Evans, C. W.; Chikhale, R. V.; Becker, R.; Morris, C. J.; Pena Martinez, C. D.; Schofield, P.; Christ, D.; Hurley, L. H.; Waller, Z. A. E.; Iyer, K. S.; Smith, N. M.
Responsible Garvan Author Professor Daniel Christ
Publisher Name JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Published Date 2020-12-31
Published Volume 142
Published Issue 49
Published Pages 20600-20604
Status Published in-print
DOI 10.1021/jacs.0c11708
URL link to publisher's version https://www.ncbi.nlm.nih.gov/pubmed/33253551