Publications
New insights on T-cell self-tolerance
Abstract
Self-tolerance of T cells is maintained by a combination of thymic negative selection and suppression by T regulatory cells (Tregs); both processes are driven by recognition of self MHC ligands. Treg function ensures that most T cells remain quiescent as naive cells, but enables some T cells to proliferate and differentiate into cells with a memory phenotype (MP). In this review, we discuss how Tregs shape this compartmentalization of T cells into subsets of naive and MP T cells.
| Type | Journal |
|---|---|
| ISBN | 1879-0372 (Electronic) 0952-7915 (Linking) |
| Authors | Yi, J.; Kawabe, T.; Sprent, J. |
| Responsible Garvan Author | Professor Jonathan Sprent |
| Publisher Name | CURRENT OPINION IN IMMUNOLOGY |
| Published Date | 2020-04-01 |
| Published Volume | 63 |
| Published Pages | 14-20 |
| Status | Published in-print |
| DOI | 10.1016/j.coi.2019.10.002 |
| URL link to publisher's version | https://www.ncbi.nlm.nih.gov/pubmed/31786417 |