Publications
SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes
Abstract
We investigated SARS-CoV-2 potential tropism by surveying expression of viral entry-associated genes in single-cell RNA-sequencing data from multiple tissues from healthy human donors. We co-detected these transcripts in specific respiratory, corneal and intestinal epithelial cells, potentially explaining the high efficiency of SARS-CoV-2 transmission. These genes are co-expressed in nasal epithelial cells with genes involved in innate immunity, highlighting the cells' potential role in initial viral infection, spread and clearance. The study offers a useful resource for further lines of inquiry with valuable clinical samples from COVID-19 patients and we provide our data in a comprehensive, open and user-friendly fashion at www.covid19cellatlas.org.
| Type | Journal |
|---|---|
| ISBN | 1546-170X (Electronic) 1078-8956 (Linking) |
| Authors | Sungnak, W.; Huang, N.; Becavin, C.; Berg, M.; Queen, R.; Litvinukova, M.; Talavera-Lopez, C.; Maatz, H.; Reichart, D.; Sampaziotis, F.; Worlock, K. B.; Yoshida, M.; Barnes, J. L.; Network, H. C. A. Lung Biological Network |
| Responsible Garvan Author | Professor Joseph Powell |
| Publisher Name | NATURE MEDICINE |
| Published Date | 2020-05-31 |
| Published Volume | 26 |
| Published Issue | 5 |
| Published Pages | 681-687 |
| Status | Published in-print |
| DOI | 10.1038/s41591-020-0868-6 |
| URL link to publisher's version | https://www.ncbi.nlm.nih.gov/pubmed/32327758 |