Publications
The Complexities of Metastasis
Abstract
Therapies that prevent metastatic dissemination and tumor growth in secondary organs are severely lacking. A better understanding of the mechanisms that drive metastasis will lead to improved therapies that increase patient survival. Within a tumor, cancer cells are equipped with different phenotypic and functional capacities that can impact their ability to complete the metastatic cascade. That phenotypic heterogeneity can be derived from a combination of factors, in which the genetic make-up, interaction with the environment, and ability of cells to adapt to evolving microenvironments and mechanical forces play a major role. In this review, we discuss the specific properties of those cancer cell subgroups and the mechanisms that confer or restrict their capacity to metastasize.
Type | Journal |
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ISBN | 2072-6694 (Print) 2072-6694 |
Authors | San Juan, B. P.; Garcia-Leon, M. J.; Rangel, L.; Goetz, J. G.; Chaffer, C. L. |
Responsible Garvan Author | Associate Professor Christine Chaffer |
Publisher Name | Cancers |
Published Date | 2019-10-16 |
Published Volume | 11 |
Published Issue | 10 |
Published Pages | pii: E1575 |
Status | Always Electronic |
DOI | 10.3390/cancers11101575 |
URL link to publisher's version | https://www.ncbi.nlm.nih.gov/pubmed/31623163 |