Publications
Protein A superantigen: structure, engineering and molecular basis of antibody recognition
Abstract
Staphylococcus aureus interacts with the human immune system through the production of secreted factors. Key among these is protein A, a B-cell superantigen capable of interacting with both antibody Fc and VH regions. Here, we review structural and molecular features of this important example of naturally occurring bacterial superantigens, as well as engineered variants and their application in biotechnology.
| Type | Journal |
|---|---|
| ISBN | 1741-0134 (Electronic) 1741-0126 (Linking) |
| Authors | Mazigi, O.; Schofield, P.; Langley, D. B.; Christ, D. |
| Responsible Garvan Author | Professor Daniel Christ |
| Publisher Name | Protein Eng |
| Published Date | 2019-12-01 |
| Published Volume | 32 |
| Published Issue | 8 |
| Published Pages | 359-366 |
| Status | Published in-print |
| DOI | 10.1093/protein/gzz026 |
| URL link to publisher's version | https://www.ncbi.nlm.nih.gov/pubmed/31641749 |