Publications
MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition
Abstract
Inhibition of the NLRP3 inflammasome is a promising strategy for the development of new treatments for inflammatory diseases. MCC950 is a potent and specific small-molecule inhibitor of the NLRP3 pathway, but its molecular target is not defined. Here, we show that MCC950 directly interacts with the Walker B motif within the NLRP3 NACHT domain, thereby blocking ATP hydrolysis and inhibiting NLRP3 activation and inflammasome formation.
| Type | Journal |
|---|---|
| ISBN | 1552-4450 |
| Authors | Coll, R. C.; Hill, J. R.; Day, C. J.; Zamoshnikova, A.; Boucher, D.; Massey, N. L.; Chitty, J. L.; Fraser, J. A.; Jennings, M. P.; Robertson, A. A. B.; Schroder, K. |
| Responsible Garvan Author | Jessica Chitty |
| Publisher Name | Nature Chemical Biology |
| Published Date | 2019-06-01 |
| Published Volume | 15 |
| Published Issue | 6 |
| Published Pages | 556-559 |
| Status | Published in-print |
| DOI | 10.1038/s41589-019-0277-7 |
| URL link to publisher's version | https://www.ncbi.nlm.nih.gov/pubmed/31086327 |