Publications
The Importance of mTOR Trafficking for Human Skeletal Muscle Translational Control
Abstract
The mechanistic target of rapamycin (mTOR) is a central regulator of muscle protein synthesis, and its activation has long been attributed to its translocation to the lysosome. Here we present a novel model of mTOR activation in skeletal muscle where the translocation of mTOR and the lysosome toward the cell membrane is a key process in mTOR activation.
| Type | Journal |
|---|---|
| ISBN | 1538-3008 (Electronic) 0091-6331 (Linking) |
| Authors | Hodson, N.; Philp, A. |
| Responsible Garvan Author | Dr Andy Philp |
| Publisher Name | EXERCISE AND SPORT SCIENCES REVIEWS |
| Published Date | 2018-01-07 |
| Published Volume | 47 |
| Published Issue | 1 |
| Published Pages | 46-53 |
| Status | Published in-print |
| DOI | 10.1249/JES.0000000000000173 |
| URL link to publisher's version | https://www.ncbi.nlm.nih.gov/pubmed/30334852 |
| OpenAccess link to author's accepted manuscript version | https://publications.gimr.garvan.org.au/open-access/14760 |