Publications
TCR tuning of T cell subsets
Abstract
After selection in the thymus, the post-thymic T cell compartments comprise heterogenous subsets of naive and memory T cells that make continuous T cell receptor (TCR) contact with self-ligands bound to major histocompatibility complex (MHC) molecules. T cell recognition of self-MHC ligands elicits covert TCR signaling and is particularly important for controlling survival of naive T cells. Such tonic TCR signaling is tightly controlled and maintains the cells in a quiescent state to avoid autoimmunity. Here, we review how naive and memory T cells are differentially tuned and wired for TCR sensitivity to self and foreign ligands.
Type | Journal |
---|---|
ISBN | 1600-065X (Electronic) 0105-2896 (Linking) |
Authors | Cho, J. H.; Sprent, J. |
Responsible Garvan Author | Professor Jonathan Sprent |
Publisher Name | IMMUNOLOGICAL REVIEWS |
Published Date | 2018-05-01 |
Published Volume | 283 |
Published Issue | 1 |
Published Pages | 129-137 |
Status | Always Electronic |
DOI | 10.1111/imr.12646 |
URL link to publisher's version | https://www.ncbi.nlm.nih.gov/pubmed/29664578 |