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Human plasma C3 is essential for the development of memory B, but not T, lymphocytes

Abstract

Primary or secondary plasma C3 deficiency due to mutations in C3 or in complement Factor I impairs memory B, but not T, cell differentiation, but does not preclude intracellular C3 fragment expression in lymphocytes.

Type Letter
ISBN 1097-6825 (Electronic) 0091-6749 (Linking)
Authors Jimenez-Reinoso, A.; Marin, A. V.; Subias, M.; Lopez-Lera, A.; Roman-Ortiz, E.; Payne, K.; Ma, C. S.; Arbore, G.; Kolev, M.; Freeley, S. J.; Kemper, C.; Tangye, S. G.; Fernandez-Malave, E.; Rodriguez de Cordoba, S.; Lopez-Trascasa, M.; Regueiro, J. R.
Responsible Garvan Author Professor Stuart Tangye
Publisher Name JOURNAL OF CLINICAL IMMUNOLOGY
Published Date 2018-03-01
Published Volume 141
Published Issue 3
Published Pages 1153-1154
Status Published in-print
DOI 10.1016/j.jaci.2017.09.037
URL link to publisher's version https://www.ncbi.nlm.nih.gov/pubmed/29113906